Moreover, the findings of a very high similarity between the transcriptomes of placenta and hemangioma provide strong support for this theory. Furthermore 

A hemangioma or haemangioma is a usually benign vascular tumor derived from blood vessel cell types. The most common form is infantile hemangioma, known colloquially as a "strawberry mark", most commonly seen on the skin at birth or in the first weeks of life.A hemangioma can occur anywhere on the body, but most commonly appears on the face, scalp, chest or back.

(2001) Arch. Dermatol. 137, 559-570]. Infantile (juvenile) capillary hemangiomas are vascular neoplasms which can appear quite infiltrative histologically and are characterized by cords of cells with areas of marked cellularity. While vessels can be distinguished in most cases, there are many cells which do not appear to be endothelial in origin. Infantile hemangioma (IH) is a common vascular tumor of infancy.

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It is often challenging for clinicians to predict which tumors are in need of systemic treatment. However, data from various demographic and other studies have revealed further of human placenta and infantile hemangioma are sufficiently similar to suggest a placental origin for this tumor, expanding on recent immunophenotypical studies that have suggested this pos-sibility[North,P.E.,etal.(2001)Arch.Dermatol.137,559–570].The transcriptomes of placenta, hemangioma, and eight normal and Further, infantile hemangioma (IH) shares various histochemical and genetic characteristics with placental endothelial cells; notably, a predictable life cycle of initial proliferation followed by apoptotic involution similarly to that of the placenta. These findings suggest the possibility that the placenta could be the origin site of IH. 2017-02-28 Infantile hemangioma may originate from the embryonic mesoderm, a pericyte or endothelial precursor, or localized angioblasts. According to the intrinsic theory, infantile hemangioma originates from vasculogenesis, a process by which new blood vessels are formed.

The placenta releases angiostatic factors (sFLT1), but after birth these inhibitory factors are wasted, which allows the development of the infantile hemangioma by endothelial cell proliferation

Typically they begin during the first four weeks of life, grow until about five months of life, and then shrink in size over the next few years. Often skin changes remain following involution. of human placenta and infantile hemangioma are sufficiently similar to suggest a placental origin for this tumor, expanding on recent immunophenotypical studies that have suggested this pos-sibility [North, P. E., et al. (2001) Arch.

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While vessels can be distinguished in most cases, there are many cells which do not appear to be endothelial in origin. Infantile hemangioma (IH) is a common vascular tumor of infancy.

North et al documented in 2001 the expression of placental vascular epitopes in hemangiomas, suggesting the origin of these tumors from placental endothelial cells or their precursors ( 2–4 ). In their investigation of other tissues, the authors found that the placenta showed an identical phenotype with regard to these markers. 2 Further study has been carried out by Dr Carmen Barnes, working at Boston Children’s Hospital, who discovered that the placenta and the infantile hemangioma have high levels of transcriptome similarity when compared with normal skin and seven other normal Infantile haemangioma is usually a clinical diagnosis and investigations are not routinely indicated.
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Although benign, infants with IH can experience complications including ulceration, visual and airway impairment, and residual scarring and disfigurement. It is often challenging for clinicians to predict which tumors are in need of systemic treatment. However, data from various demographic and other studies have revealed further Infantile hemangioma may originate from the embryonic mesoderm, a pericyte or endothelial precursor, or localized angioblasts. According to the intrinsic theory, infantile hemangioma originates from vasculogenesis, a process by which new blood vessels are formed. In this study, using the placental origin theory as a basis, we set out to explore whether hemangioma endothelial cells (HEC) were maternal in origin.

This review focuses on the placental theory, which proposes that a fetal placental progenitor is the cell type of origin for infantile hemangioma. The placental theory of hemangioma growth originated from the work developed by North et al (2002) who discovered that the histology and molecular markers unique to placental tissue, namely GLUT1, This review focuses on the placental theory, which proposes that a fetal placental progenitor is the cell type of origin for infantile hemangioma. Special emphasis will be placed on placental vasculogenesis and the presence and transit of placental progenitor cells during gestation. Background: The unique immunobiology of the placental trophoblast and the increased incidence of hemangiomas in infants born after chorionic villus sampling suggest that an immunologically regulated ectopic focus of trophoblasts could be the cell of origin for proliferative infantile hemangiomas.
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Infantile hemangioma (IH) is a common vascular tumor of infancy. Although benign, infants with IH can experience complications including ulceration, visual and airway impairment, and residual scarring and disfigurement. It is often challenging for clinicians to predict which tumors are in need of systemic treatment. However, data from various demographic and other studies have revealed further

137, 559-570]. The transcriptomes of placenta, hemangioma, and eight normal and Infantile hemangioma forming hemangioma. This theory the investigators noted a threefold increase in pathologic changes suggestive of hypoxia in the placenta of infants with hemangioma The placenta releases angiostatic factors (sFLT1), but after birth these inhibitory factors are wasted, which allows the development of the infantile hemangioma by endothelial cell proliferation Certain aspects of the biology of infantile hemangioma cells suggest a relationship to the placenta as a possible site of origin for the hemangioma precursor cells. In this article, a relationship between the placenta, with or without a chorangioma and the hemangioma sites of localization, is hypothesized. Se hela listan på emedicine.medscape.com Abstract.